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Diagram showing the neural pathway from the somatosensory cortex to the spinal cord and brainstem, illustrating differences in response to indentation force between control and disrupted spinal cord functions, with graphs and scatter plots depicting functional responses under various conditions.

Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain

Chirila, Anda M., Rankin, Genelle, Tseng, Shih-Yi, Emanuel, Alan J., Chavez-Martinez, Carmine L., Zhang, Dawei, Harvey, Christopher D., Ginty, David D.

Cell, vol. 185, no. 24, 2022, pp. 4541-4559.e23.

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Rankin, Genelle, Chirila, Anda M., Emanuel, Alan J., Zhang, Zihe, Woolf, Clifford J., Drugowitsch, Jan, Ginty, David D. "Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons." Cell Reports, vol. 43, no. 2, 2024, pp. 113718. Full Text

Meltzer, Shan, Boulanger, Katelyn C., Chirila, Anda M., Osei-Asante, Emmanuella, DeLisle, Michelle, Zhang, Qiyu, Kalish, Brian T., Tasnim, Aniqa, Huey, Erica L., Fuller, Leah C., Flaherty, Erin K., Maniatis, Tom, Garrett, Andrew M., Weiner, Joshua A., Ginty, David D. "γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons." Neuron, vol. 111, no. 11, 2023, pp. 1776-1794.e10. Full Text

Chirila, Anda M., Rankin, Genelle, Tseng, Shih-Yi, Emanuel, Alan J., Chavez-Martinez, Carmine L., Zhang, Dawei, Harvey, Christopher D., Ginty, David D. "Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain." Cell, vol. 185, no. 24, 2022, pp. 4541-4559.e23. Full Text

Kloc, Michelle L., Pradier, Bruno, Chirila, Anda M., Kauer, Julie A. "NMDA receptor activation induces long-term potentiation of glycine synapses." PLOS ONE, vol. 14, no. 9, 2019, pp. e0222066. Full Text

Orefice, Lauren L., Mosko, Jacqueline R., Morency, Danielle T., Wells, Michael F., Tasnim, Aniqa, Mozeika, Shawn M., Ye, Mengchen, Chirila, Anda M., Emanuel, Alan J., Rankin, Genelle, Fame, Ryann M., Lehtinen, Maria K., Feng, Guoping, Ginty, David D. "Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models." Cell, vol. 178, no. 4, 2019, pp. 867-886.e24. Full Text

Abraira, Victoria E., Kuehn, Emily D., Chirila, Anda M., Springel, Mark W., Toliver, Alexis A., Zimmerman, Amanda L., Orefice, Lauren L., Boyle, Kieran A., Bai, Ling, Song, Bryan J., Bashista, Karleena A., O'Neill, Thomas G., Zhuo, Justin, Tsan, Connie, Hoynoski, Jessica, Rutlin, Michael, Kus, Laura, Niederkofler, Vera, Watanabe, Masahiko, Dymecki, Susan M., Nelson, Sacha B., Heintz, Nathaniel, Hughes, David I., Ginty, David D. "The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn." Cell, vol. 168, no. 1-2, 2017, pp. 295-310.e19. Full Text

Orefice, Lauren L., Zimmerman, Amanda L., Chirila, Anda M., Sleboda, Steven J., Head, Joshua P., Ginty, David D. "Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs." Cell, vol. 166, no. 2, 2016, pp. 299-313. Full Text

Dingle, Yu-Ting L., Boutin, Molly E., Chirila, Anda M., Livi, Liane L., Labriola, Nicholas R., Jakubek, Lorin M., Morgan, Jeffrey R., Darling, Eric M., Kauer, Julie A., Hoffman-Kim, Diane. "Three-Dimensional Neural Spheroid Culture: AnIn VitroModel for Cortical Studies." Tissue Engineering Part C: Methods, vol. 21, no. 12, 2015, pp. 1274-1283. Full Text

Chirila, Anda M., Brown, Travis E., Bishop, Rachel A., Bellono, Nicholas W., Pucci, Francesco G., Kauer, Julie A. "Long-term potentiation of glycinergic synapses triggered by interleukin 1β." Proceedings of the National Academy of Sciences, vol. 111, no. 22, 2014, pp. 8263-8268. Full Text

Brown TE, Chirila, Anda M., Schrank BR, Kauer JA. "Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice." Hippocampus, vol. 23, no. 8, 2013, pp. 662-671. Full Text

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